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The latest earthquakes have proven that several existing buildings, particularly in developing countries, are not secured from damages of earthquake. A variety of statistical and machine-learning approaches have been proposed to identify vulnerable buildings for the prioritization of retrofitting. The present work aims to investigate earthquake susceptibility through the combination of six building performance variables that can be used to obtain an optimal prediction of the damage state of reinforced concrete buildings using artificial neural network (ANN). In this regard, a multi-layer perceptron network is trained and optimized using a database of 484 damaged buildings from the Düzce earthquake in Turkey. The results demonstrate the feasibility and effectiveness of the selected ANN approach to classify concrete structural damage that can be used as a preliminary assessment technique to identify vulnerable buildings in disaster risk-management programs.