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This study investigates the performance of two systems: personalized ventilation (PV) and ductless personalized ventilation (DPV). Even though the literature indicates a compelling performance of PV, it is not often used in practice due to its impracticality. Therefore, the present study assesses the possibility of replacing the inflexible PV with DPV in office rooms equipped with displacement ventilation (DV) in the summer season. Numerical simulations were utilized to evaluate the inhaled concentration of pollutants when PV and DPV are used. The systems were compared in a simulated office with two occupants: a susceptible occupant and a source occupant. Three types of pollution were simulated: exhaled infectious air, dermally emitted contamination, and room contamination from a passive source. Results indicated that PV improved the inhaled air quality regardless of the location of the pollution source; a higher PV supply flow rate positively impacted the inhaled air quality. Contrarily, the performance of DPV was highly sensitive to the source location and the personalized flow rate. A higher DPV flow rate tends to decrease the inhaled air quality due to increased mixing of pollutants in the room. Moreover, both systems achieved better results when the personalized system of the source occupant was switched off.