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A stress based remodeling approach is used to investigate the sensitivity of the collagen architecture in humane eye tissues on the biomechanical response of the lamina cribrosa with a particular focus on the stress environment of the nerve fibers. This approach is based on a multi-level biomechanical framework, where the biomechanical properties of eye tissues are derived from a single crimped fibril at the micro-scale via the collagen network of distributed fibrils at the meso-scale to the incompressible and anisotropic soft tissue at the macro-scale. Biomechanically induced remodeling of the collagen network is captured on the meso-scale by allowing for a continuous reorientation of collagen fibrils. To investigate the multi-scale phenomena related to glaucomatous neuropathy a generalized computational homogenization scheme is applied to a coupled two-scale analysis of the human eye considering a numerical macro- and meso-scale model of the lamina cribrosa.