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The sizing of simple resonators like guitar strings or laser mirrors is directly connected to the wavelength and represents no complex optimisation problem. This is not the case with liquid-filled acoustic resonators of non-trivial geometries, where several masses and stiffnesses of the structure and the fluid have to fit together. This creates a scenario of many competing and interacting resonances varying in relative strength and frequency when design parameters change. Hence, the resonator design involves a parameter-tuning problem with many local optima. As its solution evolutionary algorithms (EA) coupled to a forced-harmonic FE simulation are presented. A new hybrid EA is proposed and compared to two state-of-theart EAs based on selected test problems. The motivating background is the search for better resonators suitable for sonofusion experiments where extreme states of matter are sought in collapsing cavitation bubbles.