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This paper describes the application of interval calculus to calculation of plate deflection, taking in account inevitable and acceptable tolerance of input data (input parameters). The simply supported reinforced concrete plate was taken as an example. The plate was loaded by uniformly distributed loads. Several parameters that influence the plate deflection are given as certain closed intervals. Accordingly, the results are obtained as intervals so it was possible to follow the direct influence of a change of one or more input parameters on output (in our example, deflection) values by using one model and one computing procedure. The described procedure could be applied to any FEM calculation in order to keep calculation tolerances, ISO-tolerances, and production tolerances in close limits (admissible limits). The Wolfram Mathematica has been used as tool for interval calculation.