MULTISCALE MODELING AND COMPUTATIONAL REMODELING OF HUMAN EYE TISSUES

  • A stress based remodeling approach is used to investigate the sensitivity of the collagen architecture in humane eye tissues on the biomechanical response of the lamina cribrosa with a particular focus on the stress environment of the nerve fibers. This approach is based on a multi-level biomechanical framework, where the biomechanical properties of eye tissues are derived from a single crimped fibril at the micro-scale via the collagen network of distributed fibrils at the meso-scale to the incompressible and anisotropic soft tissue at the macro-scale. Biomechanically induced remodeling of the collagen network is captured on the meso-scale by allowing for a continuous reorientation of collagen fibrils. To investigate the multi-scale phenomena related to glaucomatous neuropathy a generalized computational homogenization scheme is applied to a coupled two-scale analysis of the human eye considering a numerical macro- and meso-scale model of the lamina cribrosa.

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Metadaten
Document Type:Conference Proceeding
Author: Günther Meschke, Rafael Grytz
DOI (Cite-Link):https://doi.org/10.25643/bauhaus-universitaet.2871Cite-Link
URN (Cite-Link):https://nbn-resolving.org/urn:nbn:de:gbv:wim2-20170314-28712Cite-Link
URL:http://euklid.bauing.uni-weimar.de/ikm2009/paper.html
ISSN:1611-4086
Editor: Klaus GürlebeckGND, Carsten KönkeORCiDGND
Language:English
Date of Publication (online):2017/03/14
Date of first Publication:2010/07/14
Release Date:2017/03/14
Publishing Institution:Bauhaus-Universität Weimar
Creating Corporation:Bauhaus-Universität Weimar
Institutes:Bauhaus-Universität Weimar / In Zusammenarbeit mit der Bauhaus-Universität Weimar
Pagenumber:7
Tag:Computer Science Models in Engineering; Multiscale and Multiphysical Models; Scientific Computing
GND Keyword:Angewandte Informatik; Angewandte Mathematik; Architektur <Informatik>; Computerunterstütztes Verfahren
Dewey Decimal Classification:000 Informatik, Informationswissenschaft, allgemeine Werke / 000 Informatik, Wissen, Systeme
500 Naturwissenschaften und Mathematik / 510 Mathematik
BKL-Classification:31 Mathematik / 31.80 Angewandte Mathematik
56 Bauwesen / 56.03 Methoden im Bauingenieurwesen
Collections:Bauhaus-Universität Weimar / Internationales Kolloquium über Anwendungen der Informatik und Mathematik in Architektur und Bauwesen, IKM, Weimar / Internationales Kolloquium über Anwendungen der Informatik und Mathematik in Architektur und Bauwesen, IKM, Weimar, 18. 2009
Licence (German):License Logo Creative Commons 4.0 - Namensnennung-Nicht kommerziell (CC BY-NC 4.0)