TY - CHAP A1 - Meschke, Günther A1 - Grytz, Rafael ED - Gürlebeck, Klaus ED - Könke, Carsten T1 - MULTISCALE MODELING AND COMPUTATIONAL REMODELING OF HUMAN EYE TISSUES N2 - A stress based remodeling approach is used to investigate the sensitivity of the collagen architecture in humane eye tissues on the biomechanical response of the lamina cribrosa with a particular focus on the stress environment of the nerve fibers. This approach is based on a multi-level biomechanical framework, where the biomechanical properties of eye tissues are derived from a single crimped fibril at the micro-scale via the collagen network of distributed fibrils at the meso-scale to the incompressible and anisotropic soft tissue at the macro-scale. Biomechanically induced remodeling of the collagen network is captured on the meso-scale by allowing for a continuous reorientation of collagen fibrils. To investigate the multi-scale phenomena related to glaucomatous neuropathy a generalized computational homogenization scheme is applied to a coupled two-scale analysis of the human eye considering a numerical macro- and meso-scale model of the lamina cribrosa. KW - Angewandte Informatik KW - Angewandte Mathematik KW - Architektur KW - Computerunterstütztes Verfahren KW - Computer Science Models in Engineering; Multiscale and Multiphysical Models; Scientific Computing Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:gbv:wim2-20170314-28712 UR - http://euklid.bauing.uni-weimar.de/ikm2009/paper.html SN - 1611-4086 ER -