@inproceedings{MeschkeGrytz, author = {Meschke, G{\"u}nther and Grytz, Rafael}, title = {MULTISCALE MODELING AND COMPUTATIONAL REMODELING OF HUMAN EYE TISSUES}, editor = {G{\"u}rlebeck, Klaus and K{\"o}nke, Carsten}, organization = {Bauhaus-Universit{\"a}t Weimar}, issn = {1611-4086}, doi = {10.25643/bauhaus-universitaet.2871}, url = {http://nbn-resolving.de/urn:nbn:de:gbv:wim2-20170314-28712}, pages = {7}, abstract = {A stress based remodeling approach is used to investigate the sensitivity of the collagen architecture in humane eye tissues on the biomechanical response of the lamina cribrosa with a particular focus on the stress environment of the nerve fibers. This approach is based on a multi-level biomechanical framework, where the biomechanical properties of eye tissues are derived from a single crimped fibril at the micro-scale via the collagen network of distributed fibrils at the meso-scale to the incompressible and anisotropic soft tissue at the macro-scale. Biomechanically induced remodeling of the collagen network is captured on the meso-scale by allowing for a continuous reorientation of collagen fibrils. To investigate the multi-scale phenomena related to glaucomatous neuropathy a generalized computational homogenization scheme is applied to a coupled two-scale analysis of the human eye considering a numerical macro- and meso-scale model of the lamina cribrosa.}, subject = {Angewandte Informatik}, language = {en} }